Vascular Dementia Team

The global and domestic population of dementia patients is increasing annually, with vascular dementia ranking second only to Alzheimer’s disease in terms of etiology. Dementia can be triggered by strokes, and cerebrovascular diseases can lead to cognitive decline even without stroke. Research in this field has been relatively limited in the past, with many unanswered questions and a lack of treatment options.

Our center’s vascular dementia team focuses on various research directions, including the disease progression and risk factors for cognitive impairment after stroke, changes in neurovascular regulation after stroke and their impact on cognitive function, the role of remote biosignal monitoring in post-stroke cognitive changes at home, and blood biomarkers for cognitive impairment after stroke. In the future, we will incorporate imaging analysis to better understand the bidirectional influence of cerebral blood flow and brain function, thus elucidating the pathophysiological mechanisms of cerebral blood flow disorders in neurodegenerative diseases.

Our team consists of clinical physicians, epidemiology experts, bioinformatics specialists, and basic neuroscience researchers. We meet monthly, establish a cloud database, and aggregate data from various research sub-teams in the hope of finding a solution to vascular dementia.

Publications:

1. Bamodu OA, Chan L, Wu C-H, Yu S-F and Chung C-C. Beyond diagnosis: Leveraging routine blood and urine biomarkers to predict severity and functional outcome in acute ischemic stroke. Heliyon 2024.

2. Banda KJ, Wu K-C, Jen H-J, Chu H, Pien L-C, Chen R, et al. Comparative effectiveness of combined and single Neurostimulation and traditional dysphagia therapies for post-stroke dysphagia: a network Meta-analysis. Neurorehabilitation and Neural Repair 2023;37(4):194-204.

3. Chen C-H, Lee C-W, Hsieh Y-C, Lin C-J, Chen Y-W, Lin K-H, et al. Comparing Low-or Standard-Dose Alteplase in Endovascular Thrombectomy: Insights From a Nationwide Registry. Stroke 2024.

4. Chen J-H, Lin S-C, Hong C-T and Chan L. Outcomes of Endovascular Treatment versus Standard Medical Treatment for Acute Ischemic Stroke with Basilar Artery Occlusion: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine 2023;12(20):6444.

5. Do PT, Chuang D-M, Wu C-C, Huang C-Z, Chen Y-H, Kang S-J, et al. Mesenchymal Stem Cells Overexpressing FGF21 Preserve Blood-Brain Barrier Integrity in Experimental Ischemic Stroke. Translational Stroke Research 2023:1-11.

6. Fang Y-C, Hsieh Y-C, Hu C-J and Tu Y-K. Endothelial dysfunction in neurodegenerative diseases. International journal of molecular sciences 2023;24(3):2909.

7. Huang W-C, Shu L-H, Kuo Y-J, Lai KS-L, Hsia C-W, Yen T-L, et al. Eugenol Suppresses Platelet Activation and Mitigates Pulmonary Thromboembolism in Humans and Murine Models. International Journal of Molecular Sciences 2024;25(4):2098.

8. Huang Y-N, Greig NH, Huang P-S, Chiang Y-H, Hoffer A, Yang C-H, et al. Pomalidomide Improves Motor Behavioral Deficits and Protects Cerebral Cortex and Striatum Against Neurodegeneration Through a Reduction of Oxidative/Nitrosative Damages and Neuroinflammation After Traumatic Brain Injury. Cell Transplantation 2024;33:09636897241237049.

9. Lu K-J, Yang C-H, Sheu J-R, Chung C-L, Jayakumar T, Chen C-M, et al. Overexpressing glyoxalase 1 attenuates acute hyperglycemia–exacerbated neurological deficits of ischemic stroke in mice. Translational Research 2023;261:57-68.

10. Pham TT, Duong TV, Nguyen LT, Vu M-T, Pham KM, Nguyen MH, et al. Association between Hypertension and Stroke Recurrence as Modified by Pro-oxidant–Antioxidant Balance: A Multi-Center Study. Nutrients 2023;15(10):2305.

11. Pien L-C, Cheng W-J, Chang W-P, Chen S-R, Chou K-R and Wang C-H. Relationships between stroke prevalence, health literacy, and oral health-related quality of life in middle-aged and older adults: a national survey study. BMC geriatrics 2023;23(1):233.

12. Sun J-M, Yen T-L, Jan J-S, Mwale PF, Teng R-D, Taliyan R, et al. Advances in Antibody-Based Therapeutics for Cerebral Ischemia. Pharmaceutics 2022;15(1):145.

13. Sung L-C, Chang C-C, Yeh C-C, Lee C-Y, Hu C-J, Cherng Y-G, et al. The effects of regular dental scaling on the complications and mortality after stroke: a retrospective cohort study based on a real-world database. BMC Oral Health 2023;23(1):487.

14. Yang C-C, Bamodu OA, Chan L, Chen J-H, Hong C-T, Huang Y-T, et al. Risk factor identification and prediction models for prolonged length of stay in hospital after acute ischemic stroke using artificial neural networks. Frontiers in Neurology 2023;14:1085178.