Vascular Dementia Team
血管性失智團隊
Vascular Dementia Team
血管性失智團隊
團隊成員
研究亮點
研究成果
團隊成員
團隊成員順序依英文姓名排序
研究亮點
失智症成因與腦血管疾病之間錯綜複雜的病生理解密團隊
全球及國內失智症病人逐年增加，而血管性失智症佔失智症病因第二位，僅次於阿茲海默症. 腦中風後會引發失智症，而且腦血管疾病即使不中風還是會導致認知功能下降，過去這個領域研究較少，仍有許多未被解答的問題，治療上更是欠缺。
本中心血管性失智症團隊主要研究方向包括：腦中風後發生認知功能障礙的疾病歷程與風險因子，腦中風後神經腦血流調控的改變及其對認知功能的影響，在家遠距生物訊號在中風後認知功能變化之角色，還有腦中風後認知功能障礙的血液生物標記。未來將加入影像學分析以更全面了解腦血流與腦功能的雙向影響，進而釐清腦血流障礙在神經退化性疾病的病生理機轉。
我們團隊包括臨床醫師，流行病學專家，生物資訊專家，還有基礎神經科學研究人員，我們每月開會，建立雲端資料庫，彙整各個研究子團隊的數據，希望能找到血管性失智症的解方。
研究成果
發表文章：
1. Bamodu OA, Chan L, Wu C-H, Yu S-F and Chung C-C. Beyond diagnosis: Leveraging routine blood and urine biomarkers to predict severity and functional outcome in acute ischemic stroke. Heliyon 2024.
2. Banda KJ, Wu K-C, Jen H-J, Chu H, Pien L-C, Chen R, et al. Comparative effectiveness of combined and single Neurostimulation and traditional dysphagia therapies for post-stroke dysphagia: a network Meta-analysis. Neurorehabilitation and Neural Repair 2023;37(4):194-204.
3. Chen C-H, Lee C-W, Hsieh Y-C, Lin C-J, Chen Y-W, Lin K-H, et al. Comparing Low-or Standard-Dose Alteplase in Endovascular Thrombectomy: Insights From a Nationwide Registry. Stroke 2024.
4. Chen J-H, Lin S-C, Hong C-T and Chan L. Outcomes of Endovascular Treatment versus Standard Medical Treatment for Acute Ischemic Stroke with Basilar Artery Occlusion: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine 2023;12(20):6444.
5. Do PT, Chuang D-M, Wu C-C, Huang C-Z, Chen Y-H, Kang S-J, et al. Mesenchymal Stem Cells Overexpressing FGF21 Preserve Blood-Brain Barrier Integrity in Experimental Ischemic Stroke. Translational Stroke Research 2023:1-11.
6. Fang Y-C, Hsieh Y-C, Hu C-J and Tu Y-K. Endothelial dysfunction in neurodegenerative diseases. International journal of molecular sciences 2023;24(3):2909.
7. Huang W-C, Shu L-H, Kuo Y-J, Lai KS-L, Hsia C-W, Yen T-L, et al. Eugenol Suppresses Platelet Activation and Mitigates Pulmonary Thromboembolism in Humans and Murine Models. International Journal of Molecular Sciences 2024;25(4):2098.
8. Huang Y-N, Greig NH, Huang P-S, Chiang Y-H, Hoffer A, Yang C-H, et al. Pomalidomide Improves Motor Behavioral Deficits and Protects Cerebral Cortex and Striatum Against Neurodegeneration Through a Reduction of Oxidative/Nitrosative Damages and Neuroinflammation After Traumatic Brain Injury. Cell Transplantation 2024;33:09636897241237049.
9. Lu K-J, Yang C-H, Sheu J-R, Chung C-L, Jayakumar T, Chen C-M, et al. Overexpressing glyoxalase 1 attenuates acute hyperglycemia–exacerbated neurological deficits of ischemic stroke in mice. Translational Research 2023;261:57-68.
10. Pham TT, Duong TV, Nguyen LT, Vu M-T, Pham KM, Nguyen MH, et al. Association between Hypertension and Stroke Recurrence as Modified by Pro-oxidant–Antioxidant Balance: A Multi-Center Study. Nutrients 2023;15(10):2305.
11. Pien L-C, Cheng W-J, Chang W-P, Chen S-R, Chou K-R and Wang C-H. Relationships between stroke prevalence, health literacy, and oral health-related quality of life in middle-aged and older adults: a national survey study. BMC geriatrics 2023;23(1):233.
12. Sun J-M, Yen T-L, Jan J-S, Mwale PF, Teng R-D, Taliyan R, et al. Advances in Antibody-Based Therapeutics for Cerebral Ischemia. Pharmaceutics 2022;15(1):145.
13. Sung L-C, Chang C-C, Yeh C-C, Lee C-Y, Hu C-J, Cherng Y-G, et al. The effects of regular dental scaling on the complications and mortality after stroke: a retrospective cohort study based on a real-world database. BMC Oral Health 2023;23(1):487.
14. Yang C-C, Bamodu OA, Chan L, Chen J-H, Hong C-T, Huang Y-T, et al. Risk factor identification and prediction models for prolonged length of stay in hospital after acute ischemic stroke using artificial neural networks. Frontiers in Neurology 2023;14:1085178.
專長：
失智症、腦中風
動作障礙
步態障礙
週邊神經疾病
失智症、腦中風
動作障礙
步態障礙
週邊神經疾病
專長：
神經藥理學
神經幹細胞發育
認知與行為科學
神經藥理學
神經幹細胞發育
認知與行為科學
團隊成員順序依英文姓名排序
失智症成因與腦血管疾病之間錯綜複雜的病生理解密團隊
全球及國內失智症病人逐年增加，而血管性失智症佔失智症病因第二位，僅次於阿茲海默症. 腦中風後會引發失智症，而且腦血管疾病即使不中風還是會導致認知功能下降，過去這個領域研究較少，仍有許多未被解答的問題，治療上更是欠缺。
本中心血管性失智症團隊主要研究方向包括：腦中風後發生認知功能障礙的疾病歷程與風險因子，腦中風後神經腦血流調控的改變及其對認知功能的影響，在家遠距生物訊號在中風後認知功能變化之角色，還有腦中風後認知功能障礙的血液生物標記。未來將加入影像學分析以更全面了解腦血流與腦功能的雙向影響，進而釐清腦血流障礙在神經退化性疾病的病生理機轉。
我們團隊包括臨床醫師，流行病學專家，生物資訊專家，還有基礎神經科學研究人員，我們每月開會，建立雲端資料庫，彙整各個研究子團隊的數據，希望能找到血管性失智症的解方。
發表文章：
Huang, L.-K., Chao, S.-P., Hu, C.-J. (2020).Clinical trials of new drugs for Alzheimer disease. Journal of Biomedical Science,27(1)
Lin, C.-F., Hong, C.-T., Lee, W.-H., Wu, D., Hu, C.-J., Chung, C.-C.. (2020).Disseminated cutaneous herpes zoster and multiple cerebral infarcts in an adult with diabetes mellitus. Journal of NeuroVirology,26(1) 130-132
Lee, H.-H., Lin, C.-H., Lin, H.-Y., Kuei, C.-H., Zheng, J.-Q., Wang, Y.-H., Lu, L.-S., Lee, F.-P., Hu, C.-J., Wu, D., Lin, Y.-F. (2020).Histone 2A family member j drives mesenchymal transition and temozolomide resistance in glioblastoma multiforme. Cancers,12(1)
Kao, Y.-T., Hsieh, Y.-C., Hsu, C.-Y., Huang, C.-Y., Hsieh, M.-H., Lin, Y.-K., Yeh, J.-S. (2020).Comparison of the TIMI, GRACE, PAMI and CADILLAC risk scores for prediction of longterm cardiovascular outcomes in Taiwanese diabetic patients with ST-segment elevation myocardial infarction: From the registry of the Taiwan Society of Cardiology. PLoS ONE,15(2)
Wang, C.Y., Chan, L., Wu, D., Chi, W.-C., Yen, C.-F., Liao, H.-F., Hong, C.T., Liou, T.-H. (2020).Effect of Cognitive Disability and Ambulation Status on Functioning in Moderate-to-Advanced Parkinson Disease. Frontiers in Neurology,10
Lee, H.-H., Chen, C.-C., Ong, J.-R., Lin, Y.-F., Lee, F.-P., Hu, C.-J., Wang, Y.-H. (2020).Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis. Headache,60(1) 71-80
Huang, L.-K., Tsai, J.-C., Lee, H.-H., Kuan, Y.-C., Lee, Y.-T., Lin, C.-P., Chao, S.-P., Hu, C.-J. (2020).Dementia screening for elderly in-patients and its association with nursing care satisfaction-an observational study. Medicine (United States),99(2)
Kaur, N., Fang, Y.-C., Lee, H.-Y., Singh, A., Nepali, K., Lin, M.-H., Yeh, T.-K., Lai, M.-J., Chan, L., Tu, Y.-K., Banerjee, S., Hu, C.-J., Liou, J.-P. (2020).Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment. European Journal of Medicinal Chemistry,187
Chen, C.-H., Hsieh, Y.-C., Yang, P.-M., Liu, Y.-R., Cho, E.-C.(2020).Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer. Biochemical and Biophysical Research Communications,524(4) 1003-1009
Vidyanti, A.N., Hardhantyo, M., Wiratama, B.S., Prodjohardjono, A., Hu, C.-J.(2020).Obesity is less frequently associated with cognitive impairment in elderly individuals: A cross-sectional study in Yogyakarta, Indonesia. Nutrients,12(2)
Vidyanti, A.N., Hsieh, J.-Y., Lin, K.-J., Fang, Y.-C., Setyopranoto, I., Hu, C.-J. (2020).Role of HMGB1 in an animal model of vascular cognitive impairment induced by chronic cerebral hypoperfusion. International Journal of Molecular Sciences,21(6)
Chung, C.-C., Hong, C.-T., Huang, Y.-H., Su, E.C.-Y., Chan, L., Hu, C.-J., Chiu, H.-W. (2020).Predicting major neurologic improvement and long-term outcome after thrombolysis using artificial neural networks. Journal of the Neurological Sciences,410
Huang, L.-K., Chao, S.-P., Hu, C.-J. (2020).Clinical trials of new drugs for Alzheimer disease. Journal of Biomedical Science,27(1)
Lin, C.-F., Hong, C.-T., Lee, W.-H., Wu, D., Hu, C.-J., Chung, C.-C.. (2020).Disseminated cutaneous herpes zoster and multiple cerebral infarcts in an adult with diabetes mellitus. Journal of NeuroVirology,26(1) 130-132
Lee, H.-H., Lin, C.-H., Lin, H.-Y., Kuei, C.-H., Zheng, J.-Q., Wang, Y.-H., Lu, L.-S., Lee, F.-P., Hu, C.-J., Wu, D., Lin, Y.-F. (2020).Histone 2A family member j drives mesenchymal transition and temozolomide resistance in glioblastoma multiforme. Cancers,12(1)
Kao, Y.-T., Hsieh, Y.-C., Hsu, C.-Y., Huang, C.-Y., Hsieh, M.-H., Lin, Y.-K., Yeh, J.-S. (2020).Comparison of the TIMI, GRACE, PAMI and CADILLAC risk scores for prediction of longterm cardiovascular outcomes in Taiwanese diabetic patients with ST-segment elevation myocardial infarction: From the registry of the Taiwan Society of Cardiology. PLoS ONE,15(2)
Wang, C.Y., Chan, L., Wu, D., Chi, W.-C., Yen, C.-F., Liao, H.-F., Hong, C.T., Liou, T.-H. (2020).Effect of Cognitive Disability and Ambulation Status on Functioning in Moderate-to-Advanced Parkinson Disease. Frontiers in Neurology,10
Lee, H.-H., Chen, C.-C., Ong, J.-R., Lin, Y.-F., Lee, F.-P., Hu, C.-J., Wang, Y.-H. (2020).Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis. Headache,60(1) 71-80
Huang, L.-K., Tsai, J.-C., Lee, H.-H., Kuan, Y.-C., Lee, Y.-T., Lin, C.-P., Chao, S.-P., Hu, C.-J. (2020).Dementia screening for elderly in-patients and its association with nursing care satisfaction-an observational study. Medicine (United States),99(2)
Kaur, N., Fang, Y.-C., Lee, H.-Y., Singh, A., Nepali, K., Lin, M.-H., Yeh, T.-K., Lai, M.-J., Chan, L., Tu, Y.-K., Banerjee, S., Hu, C.-J., Liou, J.-P. (2020).Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment. European Journal of Medicinal Chemistry,187
Chen, C.-H., Hsieh, Y.-C., Yang, P.-M., Liu, Y.-R., Cho, E.-C.(2020).Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer. Biochemical and Biophysical Research Communications,524(4) 1003-1009
Vidyanti, A.N., Hardhantyo, M., Wiratama, B.S., Prodjohardjono, A., Hu, C.-J.(2020).Obesity is less frequently associated with cognitive impairment in elderly individuals: A cross-sectional study in Yogyakarta, Indonesia. Nutrients,12(2)
Vidyanti, A.N., Hsieh, J.-Y., Lin, K.-J., Fang, Y.-C., Setyopranoto, I., Hu, C.-J. (2020).Role of HMGB1 in an animal model of vascular cognitive impairment induced by chronic cerebral hypoperfusion. International Journal of Molecular Sciences,21(6)
Chung, C.-C., Hong, C.-T., Huang, Y.-H., Su, E.C.-Y., Chan, L., Hu, C.-J., Chiu, H.-W. (2020).Predicting major neurologic improvement and long-term outcome after thrombolysis using artificial neural networks. Journal of the Neurological Sciences,410
大腦與意識團隊
Brain and Consciousness Team
腦創傷研究團隊
Trauma Brain Injury Team
血小板生醫工程療法團隊
Platelet neurotrophins for neurorestorative biotherapy
