Vascular Dementia Team

失智症成因與腦血管疾病之間錯綜複雜的病生理解密團隊

全球及國內失智症病人逐年增加，而血管性失智症佔失智症病因第二位，僅次於阿茲海默症. 腦中風後會引發失智症，而且腦血管疾病即使不中風還是會導致認知功能下降，過去這個領域研究較少，仍有許多未被解答的問題，治療上更是欠缺。

本中心血管性失智症團隊主要研究方向包括：腦中風後發生認知功能障礙的疾病歷程與風險因子，腦中風後神經腦血流調控的改變及其對認知功能的影響，在家遠距生物訊號在中風後認知功能變化之角色，還有腦中風後認知功能障礙的血液生物標記。未來將加入影像學分析以更全面了解腦血流與腦功能的雙向影響，進而釐清腦血流障礙在神經退化性疾病的病生理機轉。

我們團隊包括臨床醫師，流行病學專家，生物資訊專家，還有基礎神經科學研究人員，我們每月開會，建立雲端資料庫，彙整各個研究子團隊的數據，希望能找到血管性失智症的解方。

發表文章：
Huang, L.-K., Chao, S.-P., Hu, C.-J. (2020).Clinical trials of new drugs for Alzheimer disease. Journal of Biomedical Science,27(1)

Lin, C.-F., Hong, C.-T., Lee, W.-H., Wu, D., Hu, C.-J., Chung, C.-C.. (2020).Disseminated cutaneous herpes zoster and multiple cerebral infarcts in an adult with diabetes mellitus. Journal of NeuroVirology,26(1) 130-132

Lee, H.-H., Lin, C.-H., Lin, H.-Y., Kuei, C.-H., Zheng, J.-Q., Wang, Y.-H., Lu, L.-S., Lee, F.-P., Hu, C.-J., Wu, D., Lin, Y.-F. (2020).Histone 2A family member j drives mesenchymal transition and temozolomide resistance in glioblastoma multiforme. Cancers,12(1)

Kao, Y.-T., Hsieh, Y.-C., Hsu, C.-Y., Huang, C.-Y., Hsieh, M.-H., Lin, Y.-K., Yeh, J.-S. (2020).Comparison of the TIMI, GRACE, PAMI and CADILLAC risk scores for prediction of longterm cardiovascular outcomes in Taiwanese diabetic patients with ST-segment elevation myocardial infarction: From the registry of the Taiwan Society of Cardiology. PLoS ONE,15(2)

Wang, C.Y., Chan, L., Wu, D., Chi, W.-C., Yen, C.-F., Liao, H.-F., Hong, C.T., Liou, T.-H. (2020).Effect of Cognitive Disability and Ambulation Status on Functioning in Moderate-to-Advanced Parkinson Disease. Frontiers in Neurology,10

Lee, H.-H., Chen, C.-C., Ong, J.-R., Lin, Y.-F., Lee, F.-P., Hu, C.-J., Wang, Y.-H. (2020).Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis. Headache,60(1) 71-80

Huang, L.-K., Tsai, J.-C., Lee, H.-H., Kuan, Y.-C., Lee, Y.-T., Lin, C.-P., Chao, S.-P., Hu, C.-J. (2020).Dementia screening for elderly in-patients and its association with nursing care satisfaction-an observational study. Medicine (United States),99(2)

Kaur, N., Fang, Y.-C., Lee, H.-Y., Singh, A., Nepali, K., Lin, M.-H., Yeh, T.-K., Lai, M.-J., Chan, L., Tu, Y.-K., Banerjee, S., Hu, C.-J., Liou, J.-P. (2020).Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment. European Journal of Medicinal Chemistry,187

Chen, C.-H., Hsieh, Y.-C., Yang, P.-M., Liu, Y.-R., Cho, E.-C.(2020).Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer. Biochemical and Biophysical Research Communications,524(4) 1003-1009

Vidyanti, A.N., Hardhantyo, M., Wiratama, B.S., Prodjohardjono, A., Hu, C.-J.(2020).Obesity is less frequently associated with cognitive impairment in elderly individuals: A cross-sectional study in Yogyakarta, Indonesia. Nutrients,12(2)

Vidyanti, A.N., Hsieh, J.-Y., Lin, K.-J., Fang, Y.-C., Setyopranoto, I., Hu, C.-J. (2020).Role of HMGB1 in an animal model of vascular cognitive impairment induced by chronic cerebral hypoperfusion. International Journal of Molecular Sciences,21(6)

Chung, C.-C., Hong, C.-T., Huang, Y.-H., Su, E.C.-Y., Chan, L., Hu, C.-J., Chiu, H.-W. (2020).Predicting major neurologic improvement and long-term outcome after thrombolysis using artificial neural networks. Journal of the Neurological Sciences,410