Vascular Dementia Team

失智症成因與腦血管疾病之間錯綜複雜的病生理解密團隊

全球及國內失智症病人逐年增加，而血管性失智症佔失智症病因第二位，僅次於阿茲海默症. 腦中風後會引發失智症，而且腦血管疾病即使不中風還是會導致認知功能下降，過去這個領域研究較少，仍有許多未被解答的問題，治療上更是欠缺。

本中心血管性失智症團隊主要研究方向包括：腦中風後發生認知功能障礙的疾病歷程與風險因子，腦中風後神經腦血流調控的改變及其對認知功能的影響，在家遠距生物訊號在中風後認知功能變化之角色，還有腦中風後認知功能障礙的血液生物標記。未來將加入影像學分析以更全面了解腦血流與腦功能的雙向影響，進而釐清腦血流障礙在神經退化性疾病的病生理機轉。

我們團隊包括臨床醫師，流行病學專家，生物資訊專家，還有基礎神經科學研究人員，我們每月開會，建立雲端資料庫，彙整各個研究子團隊的數據，希望能找到血管性失智症的解方。

發表文章

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Lee, H.-H., Lin, C.-H., Lin, H.-Y., Kuei, C.-H., Zheng, J.-Q., Wang, Y.-H., Lu, L.-S., Lee, F.-P., Hu, C.-J., Wu, D., Lin, Y.-F. (2020).Histone 2A family member j drives mesenchymal transition and temozolomide resistance in glioblastoma multiforme. Cancers,12(1)

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Vidyanti, A.N., Hsieh, J.-Y., Lin, K.-J., Fang, Y.-C., Setyopranoto, I., Hu, C.-J. (2020).Role of HMGB1 in an animal model of vascular cognitive impairment induced by chronic cerebral hypoperfusion. International Journal of Molecular Sciences,21(6)

Chung, C.-C., Hong, C.-T., Huang, Y.-H., Su, E.C.-Y., Chan, L., Hu, C.-J., Chiu, H.-W. (2020).Predicting major neurologic improvement and long-term outcome after thrombolysis using artificial neural networks. Journal of the Neurological Sciences,410