Vascular Dementia Team
血管性失智團隊
Vascular Dementia Team
血管性失智團隊
團隊成員
團隊成員順序依英文姓名排序
研究亮點
失智症成因與腦血管疾病之間錯綜複雜的病生理解密團隊
全球及國內失智症病人逐年增加，而血管性失智症佔失智症病因第二位，僅次於阿茲海默症. 腦中風後會引發失智症，而且腦血管疾病即使不中風還是會導致認知功能下降，過去這個領域研究較少，仍有許多未被解答的問題，治療上更是欠缺。
本中心血管性失智症團隊主要研究方向包括：腦中風後發生認知功能障礙的疾病歷程與風險因子，腦中風後神經腦血流調控的改變及其對認知功能的影響，在家遠距生物訊號在中風後認知功能變化之角色，還有腦中風後認知功能障礙的血液生物標記。未來將加入影像學分析以更全面了解腦血流與腦功能的雙向影響，進而釐清腦血流障礙在神經退化性疾病的病生理機轉。
我們團隊包括臨床醫師，流行病學專家，生物資訊專家，還有基礎神經科學研究人員，我們每月開會，建立雲端資料庫，彙整各個研究子團隊的數據，希望能找到血管性失智症的解方。
研究成果
發表文章
Huang, L.-K., Chao, S.-P., Hu, C.-J. (2020).Clinical trials of new drugs for Alzheimer disease. Journal of Biomedical Science,27(1)
Lin, C.-F., Hong, C.-T., Lee, W.-H., Wu, D., Hu, C.-J., Chung, C.-C.. (2020).Disseminated cutaneous herpes zoster and multiple cerebral infarcts in an adult with diabetes mellitus. Journal of NeuroVirology,26(1) 130-132
Lee, H.-H., Lin, C.-H., Lin, H.-Y., Kuei, C.-H., Zheng, J.-Q., Wang, Y.-H., Lu, L.-S., Lee, F.-P., Hu, C.-J., Wu, D., Lin, Y.-F. (2020).Histone 2A family member j drives mesenchymal transition and temozolomide resistance in glioblastoma multiforme. Cancers,12(1)
Kao, Y.-T., Hsieh, Y.-C., Hsu, C.-Y., Huang, C.-Y., Hsieh, M.-H., Lin, Y.-K., Yeh, J.-S. (2020).Comparison of the TIMI, GRACE, PAMI and CADILLAC risk scores for prediction of longterm cardiovascular outcomes in Taiwanese diabetic patients with ST-segment elevation myocardial infarction: From the registry of the Taiwan Society of Cardiology. PLoS ONE,15(2)
Wang, C.Y., Chan, L., Wu, D., Chi, W.-C., Yen, C.-F., Liao, H.-F., Hong, C.T., Liou, T.-H. (2020).Effect of Cognitive Disability and Ambulation Status on Functioning in Moderate-to-Advanced Parkinson Disease. Frontiers in Neurology,10
Lee, H.-H., Chen, C.-C., Ong, J.-R., Lin, Y.-F., Lee, F.-P., Hu, C.-J., Wang, Y.-H. (2020).Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis. Headache,60(1) 71-80
Huang, L.-K., Tsai, J.-C., Lee, H.-H., Kuan, Y.-C., Lee, Y.-T., Lin, C.-P., Chao, S.-P., Hu, C.-J. (2020).Dementia screening for elderly in-patients and its association with nursing care satisfaction-an observational study. Medicine (United States),99(2)
Kaur, N., Fang, Y.-C., Lee, H.-Y., Singh, A., Nepali, K., Lin, M.-H., Yeh, T.-K., Lai, M.-J., Chan, L., Tu, Y.-K., Banerjee, S., Hu, C.-J., Liou, J.-P. (2020).Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment. European Journal of Medicinal Chemistry,187
Chen, C.-H., Hsieh, Y.-C., Yang, P.-M., Liu, Y.-R., Cho, E.-C.(2020).Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer. Biochemical and Biophysical Research Communications,524(4) 1003-1009
Vidyanti, A.N., Hardhantyo, M., Wiratama, B.S., Prodjohardjono, A., Hu, C.-J.(2020).Obesity is less frequently associated with cognitive impairment in elderly individuals: A cross-sectional study in Yogyakarta, Indonesia. Nutrients,12(2)
Vidyanti, A.N., Hsieh, J.-Y., Lin, K.-J., Fang, Y.-C., Setyopranoto, I., Hu, C.-J. (2020).Role of HMGB1 in an animal model of vascular cognitive impairment induced by chronic cerebral hypoperfusion. International Journal of Molecular Sciences,21(6)
Chung, C.-C., Hong, C.-T., Huang, Y.-H., Su, E.C.-Y., Chan, L., Hu, C.-J., Chiu, H.-W. (2020).Predicting major neurologic improvement and long-term outcome after thrombolysis using artificial neural networks. Journal of the Neurological Sciences,410
專長：
失智症、腦中風
動作障礙
步態障礙
週邊神經疾病
失智症、腦中風
動作障礙
步態障礙
週邊神經疾病
專長：
神經藥理學
神經幹細胞發育
認知與行為科學
神經藥理學
神經幹細胞發育
認知與行為科學
團隊成員順序依英文姓名排序
失智症成因與腦血管疾病之間錯綜複雜的病生理解密團隊
全球及國內失智症病人逐年增加，而血管性失智症佔失智症病因第二位，僅次於阿茲海默症. 腦中風後會引發失智症，而且腦血管疾病即使不中風還是會導致認知功能下降，過去這個領域研究較少，仍有許多未被解答的問題，治療上更是欠缺。
本中心血管性失智症團隊主要研究方向包括：腦中風後發生認知功能障礙的疾病歷程與風險因子，腦中風後神經腦血流調控的改變及其對認知功能的影響，在家遠距生物訊號在中風後認知功能變化之角色，還有腦中風後認知功能障礙的血液生物標記。未來將加入影像學分析以更全面了解腦血流與腦功能的雙向影響，進而釐清腦血流障礙在神經退化性疾病的病生理機轉。
我們團隊包括臨床醫師，流行病學專家，生物資訊專家，還有基礎神經科學研究人員，我們每月開會，建立雲端資料庫，彙整各個研究子團隊的數據，希望能找到血管性失智症的解方。
發表文章：
Huang, L.-K., Chao, S.-P., Hu, C.-J. (2020).Clinical trials of new drugs for Alzheimer disease. Journal of Biomedical Science,27(1)
Lin, C.-F., Hong, C.-T., Lee, W.-H., Wu, D., Hu, C.-J., Chung, C.-C.. (2020).Disseminated cutaneous herpes zoster and multiple cerebral infarcts in an adult with diabetes mellitus. Journal of NeuroVirology,26(1) 130-132
Lee, H.-H., Lin, C.-H., Lin, H.-Y., Kuei, C.-H., Zheng, J.-Q., Wang, Y.-H., Lu, L.-S., Lee, F.-P., Hu, C.-J., Wu, D., Lin, Y.-F. (2020).Histone 2A family member j drives mesenchymal transition and temozolomide resistance in glioblastoma multiforme. Cancers,12(1)
Kao, Y.-T., Hsieh, Y.-C., Hsu, C.-Y., Huang, C.-Y., Hsieh, M.-H., Lin, Y.-K., Yeh, J.-S. (2020).Comparison of the TIMI, GRACE, PAMI and CADILLAC risk scores for prediction of longterm cardiovascular outcomes in Taiwanese diabetic patients with ST-segment elevation myocardial infarction: From the registry of the Taiwan Society of Cardiology. PLoS ONE,15(2)
Wang, C.Y., Chan, L., Wu, D., Chi, W.-C., Yen, C.-F., Liao, H.-F., Hong, C.T., Liou, T.-H. (2020).Effect of Cognitive Disability and Ambulation Status on Functioning in Moderate-to-Advanced Parkinson Disease. Frontiers in Neurology,10
Lee, H.-H., Chen, C.-C., Ong, J.-R., Lin, Y.-F., Lee, F.-P., Hu, C.-J., Wang, Y.-H. (2020).Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis. Headache,60(1) 71-80
Huang, L.-K., Tsai, J.-C., Lee, H.-H., Kuan, Y.-C., Lee, Y.-T., Lin, C.-P., Chao, S.-P., Hu, C.-J. (2020).Dementia screening for elderly in-patients and its association with nursing care satisfaction-an observational study. Medicine (United States),99(2)
Kaur, N., Fang, Y.-C., Lee, H.-Y., Singh, A., Nepali, K., Lin, M.-H., Yeh, T.-K., Lai, M.-J., Chan, L., Tu, Y.-K., Banerjee, S., Hu, C.-J., Liou, J.-P. (2020).Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment. European Journal of Medicinal Chemistry,187
Chen, C.-H., Hsieh, Y.-C., Yang, P.-M., Liu, Y.-R., Cho, E.-C.(2020).Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer. Biochemical and Biophysical Research Communications,524(4) 1003-1009
Vidyanti, A.N., Hardhantyo, M., Wiratama, B.S., Prodjohardjono, A., Hu, C.-J.(2020).Obesity is less frequently associated with cognitive impairment in elderly individuals: A cross-sectional study in Yogyakarta, Indonesia. Nutrients,12(2)
Vidyanti, A.N., Hsieh, J.-Y., Lin, K.-J., Fang, Y.-C., Setyopranoto, I., Hu, C.-J. (2020).Role of HMGB1 in an animal model of vascular cognitive impairment induced by chronic cerebral hypoperfusion. International Journal of Molecular Sciences,21(6)
Chung, C.-C., Hong, C.-T., Huang, Y.-H., Su, E.C.-Y., Chan, L., Hu, C.-J., Chiu, H.-W. (2020).Predicting major neurologic improvement and long-term outcome after thrombolysis using artificial neural networks. Journal of the Neurological Sciences,410
Huang, L.-K., Chao, S.-P., Hu, C.-J. (2020).Clinical trials of new drugs for Alzheimer disease. Journal of Biomedical Science,27(1)
Lin, C.-F., Hong, C.-T., Lee, W.-H., Wu, D., Hu, C.-J., Chung, C.-C.. (2020).Disseminated cutaneous herpes zoster and multiple cerebral infarcts in an adult with diabetes mellitus. Journal of NeuroVirology,26(1) 130-132
Lee, H.-H., Lin, C.-H., Lin, H.-Y., Kuei, C.-H., Zheng, J.-Q., Wang, Y.-H., Lu, L.-S., Lee, F.-P., Hu, C.-J., Wu, D., Lin, Y.-F. (2020).Histone 2A family member j drives mesenchymal transition and temozolomide resistance in glioblastoma multiforme. Cancers,12(1)
Kao, Y.-T., Hsieh, Y.-C., Hsu, C.-Y., Huang, C.-Y., Hsieh, M.-H., Lin, Y.-K., Yeh, J.-S. (2020).Comparison of the TIMI, GRACE, PAMI and CADILLAC risk scores for prediction of longterm cardiovascular outcomes in Taiwanese diabetic patients with ST-segment elevation myocardial infarction: From the registry of the Taiwan Society of Cardiology. PLoS ONE,15(2)
Wang, C.Y., Chan, L., Wu, D., Chi, W.-C., Yen, C.-F., Liao, H.-F., Hong, C.T., Liou, T.-H. (2020).Effect of Cognitive Disability and Ambulation Status on Functioning in Moderate-to-Advanced Parkinson Disease. Frontiers in Neurology,10
Lee, H.-H., Chen, C.-C., Ong, J.-R., Lin, Y.-F., Lee, F.-P., Hu, C.-J., Wang, Y.-H. (2020).Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis. Headache,60(1) 71-80
Huang, L.-K., Tsai, J.-C., Lee, H.-H., Kuan, Y.-C., Lee, Y.-T., Lin, C.-P., Chao, S.-P., Hu, C.-J. (2020).Dementia screening for elderly in-patients and its association with nursing care satisfaction-an observational study. Medicine (United States),99(2)
Kaur, N., Fang, Y.-C., Lee, H.-Y., Singh, A., Nepali, K., Lin, M.-H., Yeh, T.-K., Lai, M.-J., Chan, L., Tu, Y.-K., Banerjee, S., Hu, C.-J., Liou, J.-P. (2020).Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment. European Journal of Medicinal Chemistry,187
Chen, C.-H., Hsieh, Y.-C., Yang, P.-M., Liu, Y.-R., Cho, E.-C.(2020).Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer. Biochemical and Biophysical Research Communications,524(4) 1003-1009
Vidyanti, A.N., Hardhantyo, M., Wiratama, B.S., Prodjohardjono, A., Hu, C.-J.(2020).Obesity is less frequently associated with cognitive impairment in elderly individuals: A cross-sectional study in Yogyakarta, Indonesia. Nutrients,12(2)
Vidyanti, A.N., Hsieh, J.-Y., Lin, K.-J., Fang, Y.-C., Setyopranoto, I., Hu, C.-J. (2020).Role of HMGB1 in an animal model of vascular cognitive impairment induced by chronic cerebral hypoperfusion. International Journal of Molecular Sciences,21(6)
Chung, C.-C., Hong, C.-T., Huang, Y.-H., Su, E.C.-Y., Chan, L., Hu, C.-J., Chiu, H.-W. (2020).Predicting major neurologic improvement and long-term outcome after thrombolysis using artificial neural networks. Journal of the Neurological Sciences,410
大腦與意識團隊
Brain and Consciousness Team
腦創傷研究團隊
Trauma Brain Injury Team
血小板生醫工程療法團隊
Platelet neurotrophins for neurorestorative biotherapy
