Trauma Brain Injury Team

腦創傷團隊已經成立十幾年以上的時間，最初流行病學研究的成果，成為推動騎機車戴安全帽立法的推手，每年可防止數千名生命的喪失，進而在臨床研究及共識會議後訂定台灣的嚴重腦外傷治療指引，以及撰寫成亞洲版的嚴重腦外傷治療指引給國內、國外負責治療腦外傷醫療團隊使用。

腦外傷團隊主要的工作是長期執行對腦外傷的研究，並將研究結果用在臨床治療上。
經由研究工作對腦外傷受傷機轉及治療機制的了解，建立腦外傷精準醫學，去訂定個人化的臨床治療和復健流程，幫助病人在後續復原中可以恢復得更好。我們也準備將研究成果與市面上的生技產業結合，目前已經申請專利，也與北科大合作開發診斷工具，藉由這樣的所得再回饋到基礎研究，形成良性循環的機制。

我們也定期舉辦國內及國際會議，同時鼓勵研究教授參與國際腦外傷研究合作計畫。並且送研究生赴國外研究單位接受訓練和學習，目標是讓整個團隊可以不斷加入新血，藉由成員的年輕化與多樣化，提升研究能量，最終目標是將研究成果可以貢獻於社會。

110學年
科技部計畫共7件 (含哥倫布計畫1件)

發表文章：
Chao, P.-K., Chang, H.-F., Chang, W.-T., Yeh, T.-K., Ou, L.-C., Chuang, J.-Y., Tsu-An Hsu, J., Tao, P.-L., Loh, H.H., Shih, C., Ueng, S.-H., Yeh, S.-H. (2020).BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine. Neuropharmacology,166

Chuang, S., Ou, J.-C., Ma, H.-P. (2020).Measurement of resilience potentials in emergency departments: Applications of a tailored resilience assessment grid. Safety Science,121385-393

Chen, T.-C., Chuang, J.-Y., Ko, C.-Y., Kao, T.-J., Yang, P.-Y., Yu, C.-H., Liu, M.-S., Hu, S.-L., Tsai, Y.-T., Chan, H., Chang, W.-C., Hsu, T.-I. (2020).AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis. Redox Biology,30

Shahror, R.A., Linares, G.R., Wang, Y., Hsueh, S.-C., Wu, C.-C., Chuang, D.-M., Chiang, Y.-H., Chen, K.-Y. (2020).Transplantation of mesenchymal stem cells overexpressing fibroblast growth factor 21 facilitates cognitive recovery and enhances neurogenesis in a mouse model of traumatic brain injury. Journal of Neurotrauma,37(1) 14-26

Ahmed Ali, A.A., Shahror, R.A., Chen, K.-Y. (2020).Efficient labeling of mesenchymal stem cells for high sensitivity long-term MRI monitoring in live mice brains. International Journal of Nanomedicine,1597-114

Hung, C.-Y., Hsu, T.-I., Chuang, J.-Y., Su, T.-P., Chang, W.-C., Hung, J.-J. (2020).Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis. Molecular Neurobiology,57(1) 261-277

Feng, X.-J., Huang, Y.-T., Huang, Y.-Z., Kuo, C.-W., Peng, C.-W., Rotenberg, A., Juan, C.-H., Pei, Y.-C., Chen, Y.-H., Chen, K.-Y., Chiang, Y.-H., Liu, H.-H., Wu, J.-X., Hsieh, T.-H. (2020).Early transcranial direct current stimulation treatment exerts neuroprotective effects on 6-OHDA-induced Parkinsonism in rats. Brain Stimulation,13(3) 655-663

Lo, W.-L., Hsu, T.-I., Yang, W.-B., Kao, T.-J., Wu, M.-H., Huang, Y.-N., Yeh, S.-H., Chuang, J.-Y. (2020).Betulinic acid-mediated tuning of PERK/CHOP signaling by sp1 inhibition as a novel therapeutic strategy for glioblastoma. Cancers,12(4)

Yang, L.-Y., Greig, N.H., Tweedie, D., Jung, Y.J., Chiang, Y.-H., Hoffer, B.J., Miller, J.P., Chang, K.-H., Wang, J.-Y. (2020).The p53 inactivators pifithrin-μ and pifithrin-α mitigate TBI-induced neuronal damage through regulation of oxidative stress, neuroinflammation, autophagy and mitophagy. Experimental Neurology,324

Chen, P.-L., Lin, H.-Y., Ong, J.R., Ma, H.-P. (2020).Development of a fall-risk assessment profile for community-dwelling older adults by using the National Health Interview Survey in Taiwan. BMC Public Health,20(1)

Hsieh, T.-H., Kuo, C.-W., Hsieh, K.-H., Shieh, M.-J., Peng, C.-W., Chen, Y.-C., Chang, Y.-L., Huang, Y.-Z., Chen, C.-C., Chang, P.-K., Chen, K.-Y., Chen, H.-Y. (2020).Probiotics alleviate the progressive deterioration of motor functions in a mouse model of Parkinson’s disease. Brain Sciences,10(4)

Chiang, K.-H., Shieh, J.-M., Shen, C.-J., Chang, T.-W., Wu, P.-T., Hsu, J.-Y., Tsai, J.-P., Chang, W.-C., Chen, B.-K. (2020).Epidermal growth factor-induced COX-2 regulates metastasis of head and neck squamous cell carcinoma through upregulation of angiopoietin-like 4. Cancer Science

Leung, S.W., Lai, J.H., Chung-Che Wu, J., Tsai, Y.-R., Chen, Y.-H., Kang, S.-J., Chiang, Y.-H., Chang, C.-F., Chen, K.-Y. (2020).Neuroprotective effects of emodin against ischemia/reperfusion injury through activating erk-1/2 signaling pathway. International Journal of Molecular Sciences,21(8)

Limanjaya, I., Hsu, T.-I., Chuang, J.-Y., Kao, T.-J. (2020).L-selectin activation regulates Rho GTPase activity via Ca+2 influx in Sertoli cell line, ASC-17D cells. Biochemical and Biophysical Research Communications,525(4) 1011-101777