Sleep Medicine Team

在醫學領域中，睡眠醫學雖然發展得較晚。北醫大體系自2005年在附設醫院開啟睡眠醫學臨床服務後，目前三家附屬醫院皆設有睡眠中心，在醫學院下亦設置睡眠研究中心，同時也在校內開設多們睡眠醫學相關課程。

研究上以睡眠呼吸中止與睡眠剝奪及失眠為兩大主軸。在神經醫學領域中，睡眠具有極重要角色。睡眠不僅為大腦所有，被大腦所管理，健康的睡眠更有助於維護大腦健康。反之，睡眠剝奪及失眠，也容易影響腦神經功能，更與神經退化有緊密關係。

神經醫學研究中心的睡眠研究團隊，由不同領域的基礎與臨床研究人員所組成。進行中的研究涵蓋動物睡眠研究，人類睡眠研究與睡眠醫學實證研究。從睡眠生理的基礎，睡眠障礙的機轉，到睡眠疾病的介入，均有所涉獵並有研究成果。睡眠研究團隊，希望結合北醫大校內外的睡眠醫學研究能量，以一窺睡眠的奧秘，並為越來越盛行的睡眠疾患，提供醫療對策。

1.Associations between sleep duration and suicidality in adolescents: A systematic review and dose-response meta-analysis.
2.The neurophysiological basis of the discrepancy between objective and subjective sleep during the sleep onset period: an EEG-fMRI study.
3.Associations between sleep disturbances and suicidal ideation, plans, and attempts in adolescents a systematic review and meta-analysis.

發表文章：
Huang, L.-K., Chao, S.-P., Hu, C.-J. (2020).Clinical trials of new drugs for Alzheimer disease. Journal of Biomedical Science,27(1)

Martino, M., Magioncalda, P., Conio, B., Capobianco, L., Russo, D., Adavastro, G., Tumati, S., Tan, Z., Lee, H.-C., Lane, T.J., Amore, M., Inglese, M., Northoff, G. (2020).Abnormal Functional Relationship of Sensorimotor Network With Neurotransmitter-Related Nuclei via Subcortical-Cortical Loops in Manic and Depressive Phases of Bipolar Disorder. Schizophrenia bulletin,46(1) 163-174

Lin, C.-F., Hong, C.-T., Lee, W.-H., Wu, D., Hu, C.-J., Chung, C.-C. (2020).Disseminated cutaneous herpes zoster and multiple cerebral infarcts in an adult with diabetes mellitus. Journal of NeuroVirology,26(1) 130-132

Yang, C.-H., Di Antonio, A., Kirschen, G.W., Varma, P., Hsieh, J., Ge, S. (2020).Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain. Cell Reports,30(4) 959-968.e3

Yang, T.-H., Xirasagar, S., Cheng, Y.-F., Wu, C.-S., Kao, Y.-W., Shia, B.-C., Lin, H.-C. (2020).Association between pioglitazone use and head and neck cancer: Population-based case-control study. Head and Neck,42(4) 653-659

Marta, O.F.D., Kuo, S.-Y., Bloomfield, J., Lee, H.-C., Ruhyanudin, F., Poynor, M.Y., Brahmadhi, A., Pratiwi, I.D., Aini, N., Mashfufa, E.W., Hasan, F., Chiu, H.-Y. (2020).Gender differences in the relationships between sleep disturbances and academic performance among nursing students: A cross-sectional study. Nurse Education Today,85

Lee, H.-H., Lin, C.-H., Lin, H.-Y., Kuei, C.-H., Zheng, J.-Q., Wang, Y.-H., Lu, L.-S., Lee, F.-P., Hu, C.-J., Wu, D., Lin, Y.-F. (2020).Histone 2A family member j drives mesenchymal transition and temozolomide resistance in glioblastoma multiforme. Cancers,12(1)

Wang, C.Y., Chan, L., Wu, D., Chi, W.-C., Yen, C.-F., Liao, H.-F., Hong, C.T., Liou, T.-H. (2020).Effect of Cognitive Disability and Ambulation Status on Functioning in Moderate-to-Advanced Parkinson Disease. Frontiers in Neurology,10

Ho, J.-D., Sheu, J.-J., Kao, Y.-W., Shia, B.-C., Lin, H.-C. (2020).Associations between Attention-Deficit/Hyperactivity Disorder and Ocular Abnormalities in Children: A Population-based Study. Ophthalmic Epidemiology,27(3) 194-199

Lee, H.-H., Chen, C.-C., Ong, J.-R., Lin, Y.-F., Lee, F.-P., Hu, C.-J., Wang, Y.-H. (2020).Association of rs2651899 Polymorphism in the Positive Regulatory Domain 16 and Common Migraine Subtypes: A Meta-Analysis. Headache,60(1) 71-80

Huang, L.-K., Tsai, J.-C., Lee, H.-H., Kuan, Y.-C., Lee, Y.-T., Lin, C.-P., Chao, S.-P., Hu, C.-J. (2020).Dementia screening for elderly in-patients and its association with nursing care satisfaction-an observational study. Medicine (United States),99(2)

Chen, S.-C., Xirasagar, S., Liu, J.-C., Kao, Y.-W., Shia, B.-C., Yang, T.-H., Lin, H.-C. (2020).A population-based study of healthcare resource utilization in patients with mitral valve prolapse. International Journal of Environmental Research and Public Health,17(5)

Chi, N.-F., Huang, Y.-C., Chiu, H.-Y., Chang, H.-J., Huang, H.-C. (2020).Systematic Review and Meta-Analysis of Home-Based Rehabilitation on Improving Physical Function Among Home-Dwelling Patients With a Stroke. Archives of Physical Medicine and Rehabilitation,101(2) 359-373

Sheu, J.-R., Chen, Z.-C., Jayakumar, T., Chou, D.-S., Yen, T.-L., Lee, H.-N., Pan, S.-H., Hsia, C.-H., Yang, C.-H., Hsieh, C.-Y. (2020).Author Correction: A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice (Scientific Reports, (2017), 7, 1, (42277), 10.1038/srep42277). Scientific Reports,10(1)

Liu, C.-H., Chang, H.-M., Yang, Y.-S., Lin, Y.-T., Ho, Y.-J., Tseng, T.-J., Lan, C.-T., Li, S.-T., Liao, W.-C. (2020).Melatonin Promotes Nerve Regeneration Following End-to-Side Neurorrhaphy by Accelerating Cytoskeletal Remodeling via the Melatonin Receptor-dependent Pathway. Neuroscience,429282-292

Laksmita, O.D., Chung, M.-H., Liao, Y.-M., Chang, P.-C. (2020).Multidimensional Scale of Perceived Social Support in Indonesian adolescent disaster survivors: A psychometric evaluation. PLoS ONE,15(3)

Yang, T.-H., Xirasagar, S., Cheng, Y.-F., Wu, C.-S., Kao, Y.-W., Shia, B.-C., Lin, H.-C. (2020).Malignant Otitis Externa is Associated with Diabetes: A Population-Based Case-Control Study. Annals of Otology, Rhinology and Laryngology,Niu, X., Chuang, H.-C., Wang, X., Ho, S.S.H., Li, L., Qu, L., Chow, J.C., Watson, J.G., Sun, J., Lee, S., Cao, J., Ho, K.F. (2020).Cytotoxicity of PM2.5 vehicular emissions in the Shing Mun Tunnel, Hong Kong. Environmental Pollution,263

Kaur, N., Fang, Y.-C., Lee, H.-Y., Singh, A., Nepali, K., Lin, M.-H., Yeh, T.-K., Lai, M.-J., Chan, L., Tu, Y.-K., Banerjee, S., Hu, C.-J., Liou, J.-P. (2020).Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment. European Journal of Medicinal Chemistry,187

Vidyanti, A.N., Hardhantyo, M., Wiratama, B.S., Prodjohardjono, A., Hu, C.-J. (2020).Obesity is less frequently associated with cognitive impairment in elderly individuals: A cross-sectional study in Yogyakarta, Indonesia. Nutrients,12(2)

Hsu, A.-L., Chen, H.S.-M., Hou, P., Wu, C.W., Johnson, J.M., Noll, K.R., Prabhu, S.S., Ferguson, S.D., Kumar, V.A., Schomer, D.F., Chen, J.-H., Liu, H.-L. (2020).Presurgical resting-state functional MRI language mapping with seed selection guided by regional homogeneity. Magnetic Resonance in Medicine,84(1) 375-383

Dai, Y.-W.E., Lee, Y.-H., Li, T.-L., Hwang, L.-L. (2020).Mechanisms of orexin 2 receptor-mediated depolarization in the rat paraventricular nucleus of the hypothalamus. European Journal of Pharmacology,869

Vidyanti, A.N., Hsieh, J.-Y., Lin, K.-J., Fang, Y.-C., Setyopranoto, I., Hu, C.-J. (2020).Role of HMGB1 in an animal model of vascular cognitive impairment induced by chronic cerebral hypoperfusion. International Journal of Molecular Sciences,21(6)

Kakoty, V., K C, S., Tang, R.-D., Yang, C.H., Dubey, S.K., Taliyan, R. (2020).Fibroblast growth factor 21 and autophagy: A complex interplay in Parkinson disease. Biomedicine and Pharmacotherapy,127

Chung, C.-C., Hong, C.-T., Huang, Y.-H., Su, E.C.-Y., Chan, L., Hu, C.-J., Chiu, H.-W. (2020).Predicting major neurologic improvement and long-term outcome after thrombolysis using artificial neural networks. Journal of the Neurological Sciences,410

Magioncalda, P., Martino, M., Conio, B., Lee, H.-C., Ku, H.-L., Chen, C.-J., Inglese, M., Amore, M., Lane, T.J., Northoff, G. (2020).Intrinsic brain activity of subcortical-cortical sensorimotor system and psychomotor alterations in schizophrenia and bipolar disorder: A preliminary study. Schizophrenia Research, Liu, G.-R., Lustenberger, C., Lo, Y.-L., Liu, W.-T., Sheu, Y.-C., Wu, H.-T. (2020).Save Muscle Information-Unfiltered EEG Signal Helps Distinguish Sleep Stages. Sensors (Basel, Switzerland),20(7)