{"id":116,"date":"2019-12-02T00:15:24","date_gmt":"2019-12-01T16:15:24","guid":{"rendered":"https:\/\/www.isdesigner.net\/nrc_web\/en\/?page_id=116"},"modified":"2024-05-22T14:35:02","modified_gmt":"2024-05-22T06:35:02","slug":"neuroimage-team","status":"publish","type":"page","link":"https:\/\/nrc.tmu.edu.tw\/en\/neuroimage-team\/","title":{"rendered":"NEUROIMAGE TEAM"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"116\" class=\"elementor elementor-116\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3fc4931 elementor-section-content-middle elementor-section-full_width elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"3fc4931\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeIn&quot;,&quot;animation_mobile&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-75ea630\" data-id=\"75ea630\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ccc7dd0 animated-slow elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"ccc7dd0\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInDown&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">NeuroImage Team<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c5811ef elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"c5811ef\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInDown&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-heading-title elementor-size-small\">NEUROIMAGE TEAM<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a200895 elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"a200895\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d9d8d6e elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"d9d8d6e\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;,&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2709eae\" data-id=\"2709eae\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-124871d elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"124871d\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tHOME <i class=\"fas fa-angle-double-right\"><\/i> RESEARCH TEAMS <i class=\"fas fa-angle-double-right\"><\/i> NEUROIMAGE TEAM\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5f0de5d elementor-section-content-middle elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"5f0de5d\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1d1edaa\" data-id=\"1d1edaa\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7f12347 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7f12347\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-32ff8ca\" data-id=\"32ff8ca\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-11a59eb elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"11a59eb\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;bounceIn&quot;,&quot;_animation_delay&quot;:&quot;50&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-small\">NeuroImage Team<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eefa0f9 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"eefa0f9\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;bounceIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<strong><span style=\"font-size: 16pt;\">NEUROIMAGE TEAM<\/span><\/strong>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-f7320e1 elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"f7320e1\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;bounceIn&quot;,&quot;_animation_delay&quot;:&quot;300&quot;}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7121cda envato-kit-141-top-0 elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"7121cda\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d35d6f2\" data-id=\"d35d6f2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c8e8a4d elementor-tabs-view-horizontal elementor-widget elementor-widget-tabs\" data-id=\"c8e8a4d\" data-element_type=\"widget\" data-widget_type=\"tabs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-tabs\">\n\t\t\t<div class=\"elementor-tabs-wrapper\" role=\"tablist\" >\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2101\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2101\" aria-expanded=\"false\">Members<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2102\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2102\" aria-expanded=\"false\">Research spotlight<\/div>\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-tab-title-2103\" class=\"elementor-tab-title elementor-tab-desktop-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2103\" aria-expanded=\"false\">Research results<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"elementor-tabs-content-wrapper\" role=\"tablist\" aria-orientation=\"vertical\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"true\" data-tab=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"elementor-tab-content-2101\" aria-expanded=\"false\">Members<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2101\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2101\" tabindex=\"0\" hidden=\"false\"><p><a href=\"https:\/\/hub.tmu.edu.tw\/en\/persons\/cheng-yu-chen\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone size-full wp-image-2375\" src=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u9673\u9707\u5b87E.jpg\" alt=\"\" width=\"522\" height=\"355\" srcset=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u9673\u9707\u5b87E.jpg 522w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u9673\u9707\u5b87E-300x204.jpg 300w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u9673\u9707\u5b87E-412x280.jpg 412w\" sizes=\"(max-width: 522px) 100vw, 522px\" \/><\/a>\u00a0 \u00a0<a href=\"https:\/\/hub.tmu.edu.tw\/en\/persons\/kang-wei-chang\"><img decoding=\"async\" class=\"alignnone size-full wp-image-2372\" src=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u5f35\u525b\u744bE.jpg\" alt=\"\" width=\"522\" height=\"355\" srcset=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u5f35\u525b\u744bE.jpg 522w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u5f35\u525b\u744bE-300x204.jpg 300w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u5f35\u525b\u744bE-412x280.jpg 412w\" sizes=\"(max-width: 522px) 100vw, 522px\" \/><\/a><\/p><p>\u00a0<\/p><p><a href=\"https:\/\/hub.tmu.edu.tw\/en\/persons\/david-carroll-chen\"><img decoding=\"async\" class=\"alignnone size-full wp-image-2374\" src=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u9673\u5f65\u5ef7E.jpg\" alt=\"\" width=\"522\" height=\"355\" srcset=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u9673\u5f65\u5ef7E.jpg 522w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u9673\u5f65\u5ef7E-300x204.jpg 300w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u9673\u5f65\u5ef7E-412x280.jpg 412w\" sizes=\"(max-width: 522px) 100vw, 522px\" \/><\/a>\u00a0 \u00a0<a href=\"https:\/\/hub.tmu.edu.tw\/en\/persons\/yung-chieh-chen\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-2373\" src=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u9673\u6c38\u4ecbE.jpg\" alt=\"\" width=\"522\" height=\"355\" srcset=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u9673\u6c38\u4ecbE.jpg 522w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u9673\u6c38\u4ecbE-300x204.jpg 300w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u9673\u6c38\u4ecbE-412x280.jpg 412w\" sizes=\"(max-width: 522px) 100vw, 522px\" \/><\/a><\/p><p>\u00a0<\/p><p><a href=\"https:\/\/hub.tmu.edu.tw\/en\/persons\/sho-jen-cheng\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-2376\" src=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u912d\u78a9\u4ec1E.jpg\" alt=\"\" width=\"522\" height=\"355\" srcset=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u912d\u78a9\u4ec1E.jpg 522w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u912d\u78a9\u4ec1E-300x204.jpg 300w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u912d\u78a9\u4ec1E-412x280.jpg 412w\" sizes=\"(max-width: 522px) 100vw, 522px\" \/><\/a>\u00a0 \u00a0<a href=\"https:\/\/hub.tmu.edu.tw\/en\/persons\/kevin-li-chun-hsieh\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-2377\" src=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u8b1d\u7acb\u7fa4E.jpg\" alt=\"\" width=\"522\" height=\"355\" srcset=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u8b1d\u7acb\u7fa4E.jpg 522w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u8b1d\u7acb\u7fa4E-300x204.jpg 300w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u8b1d\u7acb\u7fa4E-412x280.jpg 412w\" sizes=\"(max-width: 522px) 100vw, 522px\" \/><\/a><\/p><p>\u00a0<\/p><p><a href=\"https:\/\/hub.tmu.edu.tw\/en\/persons\/yi-tien-li\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-2371\" src=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u674e\u5b9c\u606cE.jpg\" alt=\"\" width=\"522\" height=\"355\" srcset=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u674e\u5b9c\u606cE.jpg 522w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u674e\u5b9c\u606cE-300x204.jpg 300w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u674e\u5b9c\u606cE-412x280.jpg 412w\" sizes=\"(max-width: 522px) 100vw, 522px\" \/><\/a>\u00a0 \u00a0<a href=\"https:\/\/hub.tmu.edu.tw\/en\/persons\/yueh-hsun-lu\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-2370\" src=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u5442\u5cb3\u52f3E.jpg\" alt=\"\" width=\"522\" height=\"355\" srcset=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u5442\u5cb3\u52f3E.jpg 522w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u5442\u5cb3\u52f3E-300x204.jpg 300w, https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/2023\/08\/\u5442\u5cb3\u52f3E-412x280.jpg 412w\" sizes=\"(max-width: 522px) 100vw, 522px\" \/><\/a><\/p><p>\u00a0<\/p><p>\u00a0 \u00a0<\/p><div style=\"text-align: right;\"><span style=\"text-decoration: underline;\">Alphabet order of last name.<\/span>\u00a0<\/div><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2102\" aria-expanded=\"false\">Research spotlight<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2102\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2102\" tabindex=\"0\" hidden=\"hidden\"><p><strong><u>Research spotlight<\/u><\/strong><\/p><p>The Neuroimage Team has built multiple image platforms for animal experiments and clinical trials in an effort to promote medical imaging research, including establishment of various animal models of human disease in comparison with findings of physiological and pathological changes from clinical medicine images. Via the delicate instruments and precisely designed laboratory animal models combined with imaging studies and staining techniques, the Neuroimage Team may also help medical physicians to clarify the clinical pathology and disease diagnosis by providing evidence-based imaging results.<\/p><p>\u00a0<\/p><p>Meanwhile, the Neuroimage Team observes the various mechanisms of neuro-signal pathways on disease regulation and pharmacology through experiments in genetics, cell biology and molecular biology. As for clinical trials, the psychophysiological assessment may serve as an important prognostic indicator of diseases by reflecting the mental state and social function of patients after the onset of an illness.<\/p><p>\u00a0<\/p><p>The goal of research is to develop more effective medical image markers for early diagnosis and prognosis evaluation of diseases. By utilizing the non-invasive quantitative model of medical imaging, we may build an effective screening platform used for evaluating drug efficacy and therapeutic effects. The field of research involves genetic and cellular studies, laboratory animal experiments, and research studies on human participants. The advanced technique of translational medical imaging platform is beneficial for effective biomarkers, R&amp;D of new drugs, and translational medicine research. Apart from technical development of medical imaging, its application would support the diagnosis and treatment of four main neurological diseases.<\/p><p>\u00a0<\/p><p>The aim is to integrate relevant research teams in medical imaging at Taipei Medical University, establish advanced imaging facilities, provide consultation for both animal and human imaging research, develop advanced imaging and analysis techniques, and promote medical imaging while nurturing talent.<\/p><p>\u00a0<\/p><p>The research and development focus on translational imaging research in neurological disorders, leveraging the diverse expertise of center members. Five core laboratories have been established:<\/p><p>\u00a0<\/p><ul><li>Nanomolecular Imaging Lab<\/li><li>7T Animal Imaging Lab<\/li><li>3T Clinical Brain Functional Imaging Lab<\/li><li>Neuroimaging Biomarker Analysis Lab<\/li><li>Positron Magnetic Resonance Imaging Lab<\/li><\/ul><p>These labs span translational imaging research across different levels, from genes, cells, and animals to human studies.<\/p><p>\u00a0<\/p><p>\u00a0<\/p><p>Current research areas include:<\/p><h1>1.\u00a0\u00a0\u00a0\u00a0\u00a0 <u>Brain Tumor<\/u><\/h1><p>The research topic is mainly focused on glioblastoma multiforme(GBM). We will investigate the heterogeneity of MR imaging findings between inter- and intra-tumors, and also explore the correlation between MR imaging findings and gene mutations. We have glioblastoma cell culture with specific genetic information, such as tumor formation, angiogenesis, gene clusters associated with DNA damage and repair. Furthermore, an animal model of glioblastoma multiforme will be established at 7T MRI, and the same method can be applied to MR imaging study on human participants at 3T MRI.<\/p><p>Meanwhile, the information of gene mutation in GBM can be obtained from DNA microarray experiment, and the molecular expressions of glioblastoma multiforme with different genomic modifications are compared with MRI-based biomarkers. With the combined application of genomic information and advanced multiparametric MRI, the tumor extent can be accurately defined, the therapeutic response can be better monitored and the prognosis can be well predicted. In brief, this bedside-to-bench translational research in the Neuroimage Team is aimed to establish a radiogenomics platform based on advanced MR imaging for the purpose of understanding the genomic modification of glioblastoma multiforme and its relation with the perspective of molecular MRI.<\/p><h1>2.\u00a0\u00a0\u00a0\u00a0\u00a0 <u>Ischemic Stroke<\/u><\/h1><p>The therapeutic effect of treatment in ischemic stroke relies not only on the recovery of blood flow, but also the amount of possibly non-impaired neurons in the human brain after stroke. Within 4.5 hours after the cerebrovascular accident is usually a critical and valuable period of time to give treatments. Therefore, defining the onset time of CVA, locating the lesion sites as well as evaluating the preserved brain tissues precisely are all important factors to consider before any intervention or thrombolytic drugs injection are given.<\/p><p>There have been many MR imaging related studies in ischemic penumbra, which proposed the ischemic penumbra could be referred as the location of possibly preserved neurons. Furthermore, its area and size may be regarded as a predictor for therapeutic efficacy of pharmalogical treatments. Generally, both diffusion tensor imaging (DTI) and perfusion-weighted imaging (PWI) are advanced MRI techniques essentially for evaluating ischemic penumbra, yet the contrast agent used in PWI is not suitable for patients with certain conditions.<\/p><p>The result of our research illustrated that the multiple parameters calculated from DTI could be treated as an effective indicator for assessing the region of ischemic penumbra and estimating the onset time of ischemic stroke. It had been tested and verified in a stroke model of rats. Currently the application of laboratory research findings under the advanced MRI method has already been linked to studies involving human participants. The high availability of DTI will provide clinicians a new opportunity for diagnosis and treatment of ischemic stroke.<\/p><p>\u00a0<\/p><h1>3.\u00a0\u00a0\u00a0\u00a0\u00a0 <u>Mild Traumatic Brain Injury<\/u><\/h1><p>Mild traumatic brain injury (mTBI) is defined as the traumatic white matter injuries caused by impact-acceleration forces and may lead to the alteration of brain function or pathology. Most studies report results at the group average level, rendering little information on who might suffer from the prolonged neurocognitive symptoms or what might be the structural or functional underpinnings of disease progression. Due to the lack of the sensitive and quantitative measures of the axonal and myelin changes after mTBI, the progression of white matter pathological features that underlie prolonged neurocognitive symptoms and deficits experienced after mTBI is poorly understood.<\/p><p>Quantitative susceptibility mapping (QSM) and myelin water fraction (MWF) are the advanced quantitative magnetic resonance imaging (MRI) technique that enables us to detect myelin distribution and density for the patients with mTBI. Quantitative values derived from these quantitative MRI parametric maps are desirable as the true-quantification and vendor-independent measures which might be helpful for longitudinal evaluation of mTBI patients in the individual level.<\/p><p>Genetic factors may also modulate the axon and myelin degeneration and the vulnerability to secondary injury after mTBI, thus may account for some of the unexplained variation in outcome. Identifying the relationship between genetic signatures, imaging features, and outcome endophenotypes may produce the opportunities for early intervention, risk stratification and prognostication for mTBI.<\/p><p>\u00a0<\/p><h1>4.\u00a0\u00a0\u00a0\u00a0\u00a0 <u>Osteoporosis<\/u><\/h1><p>Osteoporosis is a metabolic bone disease that is featured with low bone mineral density (BMD) and high fracture incidence. Fractures that occur as a result of underlying osteoporosis are significantly associated with elevated mortality risk and loss of disability-adjusted life years. Loss of bone mass is one of critical characteristics of osteoporosis, which is typically diagnosed using BMD measurements. Dual energy X-ray absorptiometry (DXA) method is the most widely used method of assessing BMD. In general, BMD data could be obtained at various skeletal sites such as spine, hip and forearm. Clinically, BMD obtained from lumbar vertebrae could be regarded as major diagnosis dependency for osteoporosis.<\/p><p>\u00a0<\/p><p>Low-dose chest computed tomography (LDCT) is popularly used for early lung cancer screening with less ionizing radiation and has been demonstrated to significantly reduce mortality from lung cancer. LDCT scans generally cover the upper thoracic vertebrae. The covering part of the spine has been suggested to detect patients with osteoporosis. The utility of vertebral CT numbers derived from LDCT for detecting osteoporosis has been confirmed.<\/p><p>\u00a0<\/p><p>On the other hand, CT-based texture analysis appreciates image heterogeneities that may not be discern with the human eye, and preliminary evidence has suggested its potential value in imaging characterization for diagnostic purposes. This method is based on mathematical approaches to the evaluation of gray-level intensity and position of the pixels within the image, providing the so-called \u201ctexture features\u201d that represent a quantitative measure of heterogeneity. Patient with osteoporosis may reveal different inherent texture from normal BMD because structural integrity of trabecular bone is impaired. We hypothesized that the bone status could be related to the texture extracted from images. Therefore,we has developed a machine learning-based model based on the texture analysis, which will automatically detect osteoporosis from LDCT scans during lung cancer screening.<\/p><p>\u00a0<\/p><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-tab-title elementor-tab-mobile-title\" aria-selected=\"false\" data-tab=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"elementor-tab-content-2103\" aria-expanded=\"false\">Research results<\/div>\n\t\t\t\t\t<div id=\"elementor-tab-content-2103\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"tabpanel\" aria-labelledby=\"elementor-tab-title-2103\" tabindex=\"0\" hidden=\"hidden\"><p><span style=\"color: #0000ff;\"><em><strong><span style=\"font-size: 18pt;\">Projects<\/span><\/strong><\/em><\/span><\/p><p><strong>1. MOST Title:<\/strong> <strong>An Artificial Intelligence System for Precision Lung Cancer Based on Clinical Big Data<\/strong><\/p><p><em>Project Period: <\/em><em>2020.<\/em><em>07<\/em><em>.01<\/em><em> ~ <\/em><em>2024.06.30<\/em><\/p><p>\u00a0<\/p><p>2. \u7d93\u6fdf\u90e8\u79d1\u7814\u6210\u679c\u50f9\u503c\u5275\u9020\u8a08\u756b\u300c\u80f8\u8154\u6df1\u5ea6\u5b78\u7fd2:\u4eba\u5de5\u667a\u6167\u591a\u6a21\u5f71\u50cf\u7cbe\u6e96\u5065\u5eb7\u5e73\u53f0\u8a08\u756b\u300d<\/p><p><em>Project Period: 2023.01.01 ~ 2023.12.31<\/em><\/p><p>\u00a0<\/p><p><strong>3. NHRI Title: Develop IL-19 antibody immunotherapy and unravel immunosuppressive mechanism in peritumoral region of glioblastoma by single cell transcriptome analysis<\/strong><\/p><p><em>Project Period: 2023.01.01 ~ 2023.12.31<\/em><\/p><p>\u00a0<\/p><p><strong>4. MOST Title: Building a national model of data hub for healthy aging<\/strong><\/p><p><em>Project Period: 2021.11.01 ~ 2023.10.31<\/em><\/p><p>\u00a0<\/p><p><strong>5. MOST Title: Machine Learning-Based Radiogenomics for Connecting Mr Imaging to Immune-Regulated Genes Expression in Glioblastoma<\/strong><\/p><p><em>Project Period: 2019.08.01 ~ 2022.07.31<\/em><\/p><p><em>\u00a0<\/em><\/p><p><strong>6. NHRI Title: Multi-site Radiogenomics and Radioproteomics of gliomas<\/strong><\/p><p><em>Project Period: 2019.01.01 ~ 2020.12.31<\/em><\/p><p>\u00a0<\/p><p><strong>7. MOST Title: Construction and Application of Medical Image Database in TMU Healthcare System <\/strong><\/p><p><em>Project Period: 2017.12.01 ~ 2020.11.30<\/em><\/p><p>\u00a0<\/p><p><strong>8. MOST Title: Mri Study on Trans-Neuronal Degeneration of the Thalamic Networks after Ischemic Stroke<\/strong><\/p><p><em>Project Period: 2016.08.01 ~ 2019.10.01<\/em><\/p><p>\u00a0<\/p><p><strong>9. MOST Title: Characterization of Thalamocortical Dysrhythmia in Mild Traumatic Brain Injury Using Simultaneous Mri and Eeg Measurements and Pre-Clinical N-Acetylcysteine Treatment Response<\/strong><\/p><p><em>Project Period: 2015.08.01 ~ 2018.07.31<\/em><\/p><p>\u00a0<\/p><p><strong>10. MOST Title: Radiogenomics of Malignant Gliomas by Linking Physiological Mr Imaging, Histopathological Patterns, and Genetic Alternations: a Translational Study from Rat to Man<\/strong><\/p><p><em>Project Period: 2015.08.01 ~ 2018.07.31<\/em><\/p><p>\u00a0<\/p><p><strong>11. MOST &#8211; International Cooperation with NIH Title: Characterization of Thalamocortical Dysrhythmia in Mild Traumatic Brain Injury using Simultaneous MRI and EEG Measurements and Preclinical N-acetylcysteine Treatment Response<\/strong><\/p><p><em>Project Period: 2015.08.01 ~ 2018.07.31<\/em><\/p><p>\u00a0<\/p><p><strong>12. MOST Title: Radiogenomics of Malignant Gliomas by linking Physiological MR Imaging, Histopathological patterns, and Genetic alternations: A Translational study from Rat to Man<\/strong><\/p><p><em>Project Period: 2015.08.01 ~ 2018.07.31<\/em><\/p><p>\u00a0<\/p><p><strong>13. MOST Title: Motion-Sensitive MR Imaging in Characterizing Brain Compliance in Cerebral Venous Hypertension: A Translational Study between Humans and Rats<\/strong><\/p><p><em>Project Period: 2015.08.01 ~ 2018.07.31<\/em><\/p><p>\u00a0<\/p><p><strong>14. MOST Title: Restoration of Thalamocortical Oscillation as a Potential Treatment for mTBI: a Small Animal MRI Research<\/strong><\/p><p><em>Project Period: 2015.08.01 ~ 2018.07.31<\/em><\/p><p>\u00a0<\/p><p><strong>15. CECR Title: Advanced MR Imaging Evaluation of Primary Brain Tumor Extent and Response to Treatment<\/strong><\/p><p><em>Project Period: 2015.04.01 ~ 2016.03.31<\/em><\/p><p>\u00a0<\/p><p><strong>16. TMU Title: MR molecular imaging biomarker for treatment response prediction of metastatic lung cancer in brain: A mice model<\/strong><\/p><p><em>Project Period: 2015.04.01 ~ 2016.03.31<\/em><\/p><p>\u00a0<\/p><p><strong>17. TMU Title: Role of cerebrovenous system in intracranial compliance<\/strong><\/p><p><em>Project Period: 2014.01.01 ~ 2015.12.31<\/em><\/p><p>\u00a0<\/p><p><strong>18. MOHW Title: Advanced MR imaging evaluation of primary brain tumor extent and response to Treatment.<\/strong><\/p><p><em>Project Period: 2014.01.01 ~ 2017.12.31<\/em><\/p><p>\u00a0<\/p><p><strong>19. MOST Title: A study on trans-neuronal striato-nigral degeneration-induced movement disorders after stroke: Evaluation with grey matter suppression IR and diffusion tensor imaging<\/strong><\/p><p><em>Project Period: 2012.08.01 ~ 2015.07.31<\/em><\/p><p>\u00a0<\/p><p><strong>20. MOST Title: A study of diffusion tensor imaging as a potential surrogate marker for the management of acute ischemic cerebral stroke: A clinical and animal model at 7T<\/strong><\/p><p><em>Project Period: 2011.08.01 ~ 2014.10.31<\/em><\/p><p>\u00a0<\/p><p><strong>21. MOST Title: Pseudoresponse to Bevacizumab treatment in rat glioma: A quantitative study using magnetic nanoparticle targeting method at 7T MRI<\/strong><\/p><p><em>Project Period: 2014.11.01 ~ 2015.10.31<\/em><\/p><p>\u00a0<\/p><p><span style=\"color: #0000ff;\"><em><strong><span style=\"font-size: 18pt;\">Publications<\/span><\/strong><\/em><\/span><\/p><p><strong><span style=\"font-size: 14pt;\">1. <span style=\"font-size: 12pt;\">Automatic segmentation and radiomic texture analysis for osteoporosis screening using chest low-dose computed tomography.<\/span><\/span><\/strong><br \/><span style=\"font-size: 12pt;\">Yung-Chieh Chen\u2020, Yi-Tien Li \u2020, Po-Chih Kuo, Sho-Jen Cheng, Yi-Hsiang Chung, Duen-Pang Kuo, Cheng-Yu Chen.<\/span><br \/><span style=\"font-size: 12pt;\">European Radiology, 2023 Jan; e-pub. doi: 10.1007\/s00330-023 09421-6. (SCI, IF = 7.034, Q1)<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36719495\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36719495\/<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>2. A prospective reappraisal of motor outcome prediction in patients with acute stroke by using atlas-based diffusion tensor imaging biomarkers.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Chen YC, Cheng SJ, Hsieh LC, Shyu HY, Chen MH, Chen CY, Kuo DP.<\/span><br \/><span style=\"font-size: 12pt;\">Top Stroke Rehabil. 2023 May 20:1-12.<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37209060\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37209060\/<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>3. Personalized Prediction of Postconcussive Working Memory Decline:A Feasibility Study.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Yung-Chieh Chen\u2020, Yung-Li Chen\u2020, Duen-Pang Kuo, Yi-Tien Li*,<\/span><br \/><span style=\"font-size: 12pt;\">Yung-Hsiao Chiang, Jyh-Jong Chang, Sung-Hui Tseng, Cheng-Yu Chen. Journal of Personalized Medicine, 2022 Jan;12(2): 196. doi: 10.3390\/jpm12020196. (SCI, IF = 4.945, Q1)<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35207684\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35207684\/<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>4. Management of Patients with Adhesive Capsulitis via Ultrasound-Guided Hydrodilatation without Concomitant Intra-Articular Lidocaine Infusion: A Single-Center Experience.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Chen YC, Shen SH, Chiou HJ, Wan YL.<\/span><br \/><span style=\"font-size: 12pt;\">Life (Basel). 2022 Aug 23;12(9):1293.<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36143330\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36143330\/<\/a><\/span><\/p><p>\u00a0<\/p><p><span style=\"font-size: 12pt;\"><strong>5. Impact of physiological noise in characterizing the fuctional MRI default-mode network in Alzheimer\u2019s disease.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Yi-Tien Li, Chun-Yuan Chang, Yi-Cheng Hsu, Jong Ling Fuh, Wen-Jui Kuo, Jhy-Neng Yeh, Fa-Hsuan Lin.<\/span><br \/><span style=\"font-size: 12pt;\">Journal of Cerebral Blood Flow &amp; Metabolism, 2021 Jan;41(1):166-181. doi: 10.1177\/0271678X19897442. (SCI, IF = 6.040, Q1)<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32070180\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32070180\/<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>6. Changes in sensorimotor-related thalamic diffusion properties and cerebrospinal fluid hydrodynamics predict gait responses to tap test in idiopathic normal-pressure hydrocephalus.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Ping-Huei Tsai*,Yung-Chieh Chen,Shih-Wei Chiang,Teng-Yi Huang,Ming-Chung Chou,Hua-Shan Liu,Hsiao-Wen Chung,Giia-Sheun Peng,Hsin-I Ma,Hung-Wen Kao,Cheng-Yu Chen<\/span><br \/><span style=\"font-size: 12pt;\">Scientific Reports 2016 Nov 11;6:36650.<\/span><br \/><span style=\"font-size: 12pt;\">European Radiology (2018) 28:4504\u20134513<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29736847\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/29736847\/<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>7. Erlotinib-Conjugated Iron Oxide Nanoparticles as a Smart Cancer-Targeted Theranostic Probe for MRI.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Ahmed Atef Ahmed Ali, Fei-Ting Hsu* , Chia-Ling Hsieh, Chia-Yang Shiau, Chiao-Hsi Chiang, Zung-Hang Wei, Cheng-Yu Chen* and Hsu-Shan Huang.<\/span><br \/><span style=\"font-size: 12pt;\">Scientific Reports 2016 Nov 11;6:36650.<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27833124\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/27833124\/<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>8. Revisiting Neuroimaging of Abusive Head Trauma in Infants and Young Children.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Kevin Li-Chun Hsieh*, Robert A. Zimmerman, Hung Wen Kao and Cheng-Yu Chen*.<\/span><br \/><span style=\"font-size: 12pt;\">American Journal of Roentgenology. 2015 May 204(5):944-52.<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/www.ajronline.org\/doi\/full\/10.2214\/AJR.14.13228\">https:\/\/www.ajronline.org\/doi\/full\/10.2214\/AJR.14.13228<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>9. Curcumin Sensitizes Hepatocellular Carcinoma Cells to Radiation via Suppression of Radiation-Induced NF-kB Activity.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Hsu FT*, Liu YC, Hwang JJ.<\/span><br \/><span style=\"font-size: 12pt;\">Journal of Biomedicine and Biotechnology (2015.07 Accept).<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/www.hindawi.com\/journals\/bmri\/2015\/363671\/\">https:\/\/www.hindawi.com\/journals\/bmri\/2015\/363671\/<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>10. Advanced MR imaging of Gliomas: An Update. (Review Articles).<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Hung-Wen Kao, Shih-Wei Chiang, Hsiao-Wen Chung, Fong Y. Tsai, Cheng-Yu Chen*.<\/span><br \/><span style=\"font-size: 12pt;\">BioMed Research International. Volume 2013, Article ID 970586, 14 pages.<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/www.hindawi.com\/journals\/bmri\/2013\/970586\/\">https:\/\/www.hindawi.com\/journals\/bmri\/2013\/970586\/<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>11. Effects of Microvascular Permeability Changes on Contrast-Enhanced T1 and Pharmacokinetic MR Imagings after Ischemia.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Hua-Shan Liu*, Hsiao-Wen Chung, Ming-Chung Chou, Michelle Liou, Chao-Ying Wang, Hueng-Wen Gao, Shih-Wei Chiang, Chun-Jung Juan, Guo-Shu Huang, Cheng-Yu Chen*.<\/span><br \/><span style=\"font-size: 12pt;\">STROKE. 44(7):1872-1877, Jul 2013.<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23743977\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/23743977\/<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>12. Predicting Stroke Evolution: Comparison of susceptibility-weighted MR imaging with MR perfusion.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Kao HW, Tsai FY*, Hasso AH.<\/span><br \/><span style=\"font-size: 12pt;\">European Radiology 2012; 22: 1397-1403.<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22322311\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/22322311\/<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>13. Cerebral Thromboembolism: Value of Susceptibility weighted Imaging(SWI) in the initial diagnosis of acute infarction.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Mamlouk MD, Tsai FY*, Drachman D et al.<\/span><br \/><span style=\"font-size: 12pt;\">The Neuroradiology Journal 2012;.23:86-97.<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24028876\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/24028876\/<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>14. Susceptibility-Weighted Imaging, an additional tool to Diagnose Brain Death: Initial Experience.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">F.Y. Tsai*, K-W. Lee, H-W. Kao, C-Y. Chen.<\/span><br \/><span style=\"font-size: 12pt;\">NRJ Digital The Neuroradiology Journal 2012;2: 733-736.<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24029083\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/24029083\/<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>15. Practical Aspect of shortening susceptibility weighted imaging.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Tsai FY*, Shih YY, Tsai APH, Chan W, Chung HW.<\/span><br \/><span style=\"font-size: 12pt;\">The Neuroradiology Journal 2012;2:613-622.<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24029176\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/24029176\/<\/a><\/span><\/p><p><br \/><span style=\"font-size: 12pt;\"><strong>16. Un-Usual Acute Complication of Carotid Cavernous Fistula.<\/strong><\/span><br \/><span style=\"font-size: 12pt;\">Tsai FY*, Lee KW, Chen CJ, Cheng SJ.<\/span><br \/><span style=\"font-size: 12pt;\">The Neuroradiology J.2011;24:951-964.<\/span><br \/><span style=\"font-size: 12pt;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24059780\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/24059780\/<\/a><\/span><\/p><\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b470c91 elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"b470c91\" data-element_type=\"section\" 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href=\"\/en\/sng-pain-team\" >\n\t\t\t\t\t\tSng Pain Team\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dce1b0f elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"dce1b0f\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-0b35a7f\" data-id=\"0b35a7f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-50cd739 elementor-position-left elementor-vertical-align-middle elementor-view-default elementor-mobile-position-top elementor-invisible elementor-widget elementor-widget-icon-box\" data-id=\"50cd739\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<a href=\"\/en\/brain-and-consciousness-team\/\" class=\"elementor-icon elementor-animation-pulse\" tabindex=\"-1\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" id=\"Capa_1\" x=\"0px\" y=\"0px\" width=\"512px\" height=\"512px\" viewBox=\"0 0 162.202 162.202\" style=\"enable-background:new 0 0 162.202 162.202;\" xml:space=\"preserve\"><g><g>\t<path d=\"M145.716,88.858c0.036,0,0,2.339-1.954,4.409c-1.419,1.491-3.398,2.411-5.913,2.733c0.006,0.146,0.024,0.329,0.055,0.549   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data-original=\"#000000\" class=\"active-path\" data-old_color=\"#000000\" fill=\"#FFFFFF\"><\/path><\/g><\/g> <\/svg>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\t\t\t\t<span class=\"elementor-icon-box-title\">\n\t\t\t\t\t<a href=\"\/en\/platelet-neurotrophins-for-neurorestorative-biotherapy\" >\n\t\t\t\t\t\tPlatelet neurotrophins for neurorestorative biotherapy\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d3a9664 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"d3a9664\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a8e2232 elementor-hidden-mobile elementor-vertical-align-top elementor-invisible elementor-widget elementor-widget-icon-box\" data-id=\"a8e2232\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\t\t\t\t<span class=\"elementor-icon-box-title\">\n\t\t\t\t\t<a href=\"\/en\/neural-rehabilitation-team\" >\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1976489 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1976489\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b6f48c7 elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"b6f48c7\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-ad3a2f5 elementor-invisible\" data-id=\"ad3a2f5\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-daefa38 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"daefa38\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/nrc.tmu.edu.tw\/en\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/nrc.tmu.edu.tw\/en\/wp-content\/uploads\/elementor\/thumbs\/nrc-s-pmbofh9l4y8ul0gxmh2ouokwx9645nhjfse98coge8.png\" title=\"TAIPEI MEDICAL UNIVERSITY\ufe31RESEARCH CENTER FOR NEUROSCIENCE\" alt=\"TAIPEI MEDICAL UNIVERSITY\ufe31RESEARCH CENTER FOR NEUROSCIENCE\" class=\"elementor-animation-shrink\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-4884c47 elementor-invisible\" data-id=\"4884c47\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dec2be9 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"dec2be9\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tRESEARCH CENTER FOR NEUROSCIENCE\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4fb0dfa elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-invisible elementor-widget elementor-widget-icon-list\" data-id=\"4fb0dfa\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-phone-alt\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">886-2-6620-2589 #11225<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-envelope\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">chuning25@tmu.edu.tw<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-map-marked-alt\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">No. 301, Yuantong Rd., Zhonghe Dist., New Taipei City 235, Taiwan (R.O.C.)<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-633247b elementor-invisible\" data-id=\"633247b\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d83a1c9 elementor-align-left elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-invisible elementor-widget elementor-widget-icon-list\" data-id=\"d83a1c9\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"\/en\/about-us\/\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-user-md\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">About us<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"\/en\/organization\/\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-code-branch\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Organization<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"\/en\/research-teams\/\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-users\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Research Teams<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-2144873 elementor-invisible\" data-id=\"2144873\" data-element_type=\"column\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f610dc1 elementor-align-left elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-invisible elementor-widget elementor-widget-icon-list\" data-id=\"f610dc1\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"\/en\/category\/news\/\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-newspaper\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">News<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"\/en\/contact-us\/\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"far fa-comments\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Contact us<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"\/en\/regulations\/\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-book-reader\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Regulations<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>NeuroImage Team NEUROIMAGE TEAM HOME RESEARCH TEAMS NEU &hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":[],"_links":{"self":[{"href":"https:\/\/nrc.tmu.edu.tw\/en\/wp-json\/wp\/v2\/pages\/116"}],"collection":[{"href":"https:\/\/nrc.tmu.edu.tw\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nrc.tmu.edu.tw\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nrc.tmu.edu.tw\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nrc.tmu.edu.tw\/en\/wp-json\/wp\/v2\/comments?post=116"}],"version-history":[{"count":108,"href":"https:\/\/nrc.tmu.edu.tw\/en\/wp-json\/wp\/v2\/pages\/116\/revisions"}],"predecessor-version":[{"id":2618,"href":"https:\/\/nrc.tmu.edu.tw\/en\/wp-json\/wp\/v2\/pages\/116\/revisions\/2618"}],"wp:attachment":[{"href":"https:\/\/nrc.tmu.edu.tw\/en\/wp-json\/wp\/v2\/media?parent=116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}